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Biography
Ulvi Bayraktutan is a distinguished senior academic based at the Academic Unit of Mental Health and Clinical Neurosciences, University of Nottingham. His research focuses on the development of clinical biomarkers and innovative therapeutic strategies for pathophysiological conditions associated with neurodegeneration and endothelial dysfunction with particular emphasis on hypertension, diabetes, age-related vascular decline, stroke and other neurodegenerative conditions. Employing an integrative approach that spans preclinical, translational and clinical research, he aims to bridge the gap between laboratory discoveries and patient-centred outcomes, facilitating the translation of scientific advances into tangible health benefits.
He serves as a reviewer for many high-profile international journals and holds editorial board positions on five prestigious academic journals. He provides expert opinion or advice to a number of national and international research councils, charitable organisations, healthcare companies, professional societies and research institutions.
An Advanced Fellow of the Higher Education Academy (FHEA) since 2007, Prof Bayraktutan has also played a significant role in academic mentorship, supervising a wide range of postgraduate research projects leading to MSc, MD and PhD qualifications.
Ulvi Bayraktutan has served as the Chief investigator of the Dunhill Medical Trust EPC study which investigated the specific effects of ageing on the circulating levels and functional properties of endothelial progenitor cells (EPCs), as well as the diagnostic and prognostic value of EPCs in elderly patients with lacunar or cortical stroke.
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Expertise Summary
Keywords:
Neuroscience, blood-brain barrier, stem cells, cell-based and cell-free novel therapeutic approaches, ageing, senescence, clinical biomarkers, endothelial (dys)function, stroke, neurodegenerative diseases, neurovascular regeneration, cardiovascular diseases, experimental models of human disease, cell biology and molecular biology.
Teaching Summary
Molecular Basis of Neurodegenerative and Vascular Diseases,
Cardiovascular Risk Factors for Stroke,
Blood-Brain Barrier in Neurodegenerative Diseases,
Novel therapeutics: cell-based and cell-free options,
BMedSci projects: Lab-based projects or Literature review,
Postgraduate student teaching,
Tutorials.
Research Summary
Neuroscience
- Neurodegeneration,
- Neurodegenerative diseases,
- Blood-Brain Barrier,
- Neurovascular Unit,
- Translational Neuroscience,
- Inflammation, Oxidative Stress,
- Ischaemic injury,
- Ischaemic Stroke, Haemorrhagic Stroke,
- Multiple Sclerosis.
Ageing
- Healthy Ageing,
- Vascular Ageing,
- Age-Related Diseases: physiology, pathology, prevention,
- Senescence: replicative senescence and stress-induced senescence,
- SASP: senescence-associated secretory phenotype,
- Organismal Ageing: transcriptomics, proteomics, metabolomics,
- Senotherapeutics: senolytics, senomorphics, stem cells, therapeutic cocktails,
- Clinical Trials.
Vascular Research
- Macrovascular and Microvascular Disease,
- Cardiovascular Risk Factors: Hypertension, Hyperglycaemia, Inflammation, Ageing,
- Endothelium,
- Endothelial dysfunction as source of disease and therapeutic target.
Stem Cells / Regenerative Medicine
- Neurovascular Regeneration,
- Endothelial Progenitor Cells, Outgrowth Endothelial Cells,
- Mesenchymal Stem Cells, Haematopoietic Stem Cells, Neural Progenitor Cells,
- Clinical Biomarkers,
- Allogeneic and Autologous Cell therapy.
Selected Publications
ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (In Press.)